ENGINEERING PROJECTS OVERVIEW

2019-2020

EXPLORING THE ANTI-INFLAMMATORY EFFECTS OF BUDESONIDE FOR ASTHMATIC PATIENTS USING CEBPD ANTIBODY

  • Research conducted under the guidance of Dr. Cynthia Koziol-White Ph.D. @ Rutgers University Medical School Translational Medicine and Science Lab 

  • Identified potential inflammatory mediators whose expression is altered by steroid treatment in a CEBPD-dependent manner. CCAAT Enhancer Binding Protein Delta (CEBPD) is a transcription factor that plays a role in modulating immune and inflammatory responses as prior studies have shown that CEBPD is a steroid-responsive gene in human airway smooth muscle cells (HASMC). 

2018-2019

INCREASING THE EFFICIENCY OF THE TOPICAL MEDICATION TRIAMCINOLONE ACETONIDE IN THE ORAL CAVITY

  • Research published on the Biomedical Journal of Scientific & Technical Research (BJSTR) as the first author with co-author Dr. S.M. Lee M.D. (Lucile Packard Children’s Hospital Stanford & Professor @ Yonsei University Severance Medical Center) 

  • 2nd Place of Medical Engineering Category & IBM Award winning project @ 2019 Synopsys Silicon Valley Science and Engineering Championship

  • Independently proposed, designed, and executed a project aimed at designing a topical medication more efficient than the current commercialized triamcinolone acetonide medications by adding double emulsion droplets (DEDs) and normal oral flora Streptococcus Salivarius (SS) at various conditions.

  • Designed and Tested two different models. Model 1: the ointment acts as a base and includes double emulsion droplets that encapsulate normal oral flora. Model 2: the double emulsion droplets encapsulate both the ointment and the normal oral flora

2018

MODELING A BIOLUMINESCENT POWER SOURCE THAT ENHANCES THE BRIGHTNESS OF PHOTOBACTERIUM PHOSPHOREUM WITH OPTIMIZED DYE-SENSITIZED PLATE

  • 1st Place of Biological Sciences and Engineering Category & Women in Science Special Award-winning and California Science & Engineering Fair and qualifying project @ 2018 Santa Clara Valley Science and Engineering Fair Championship. Also one of the few first-place winners selected to join the Synopsys Science Fair Winner's Circle 

  • Independently proposed, designed, and executed a project designing a bioluminescent power source to replace light electricity using luminescent bacteria Photobacterium Phosphoreum.

  • Researched industry standards and viability of the bioluminescent power source if put to market at scale.

2016

DESIGNING A GRAPHENE BASE SOLAR CELL BY COMBINING SOLAR PHOTOVOLTAIC AND SOLAR HEAT POWER GENERATION

  • 1st Place winning project @ 2016 Korean National Science Fair 

  • Independently proposed, designed, and executed a project aimed to design Graphene-based solar cell that contains both solar photovoltaic and solar heat power generation, and determined the optimal conditions for maximum storage and output efficiency

2016

DESIGNING A NOVEL TOOTHBRUSH FOR EFFICIENT TOOTH BRUSHING TECHNIQUES IN LINGUAL ORTHODONTICS

  • 1st place winning project @ 2016 Seoul Invention Competition

  • Independently proposed and designed to create an optimal toothbrush for individuals with front and back end braces and determined the most efficient tooth brushing technique of the newly engineered toothbrush.

2016

COMPARING THE INSULATION EFFECT OF NATURAL INSULATION TO DESIGN AN ECO-FRIENDLY APARTMENT COMPLEX

  • 1st Place winning project @ 2016 Seoul Science Debate Competition

  • Researched and provided evidence for the cost-efficient benefits of Eco-friendly apartment complex designs.

  • Built a model of the optimal apartment complex and demonstrated its workings to test practicality at a smaller level.

 

THE ANTI-INFLAMMATORY EFFECTS OF BUDESONIDE FOR ASTHMATIC PATIENTS USING CEBPD ANTIBODY

CCAAT Enhancer Binding Protein Delta (CEBPD) is a transcription factor that plays a role in modulating immune and inflammatory responses. Prior studies have shown that CEBPD is a steroid-responsive gene in human airway smooth muscle (HASM). The purpose of the study is to identify potential inflammatory mediators whose expression is altered by steroid treatment in a CEBPD-dependent manner. Inflammatory mediators that modulate the immune and inflammatory responses during CEBPD-dependent treatment exists. I selected various types of mediators that would potentially affect the anti-inflammatory effects of the steroid treatment related to CEBPD. In my decisions, I was largely affected by the biological pathways regarding CEBPD. Our data suggest that the expression of certain inflammatory mediators, in response to steroid treatment, may depend on the presence of CEBPD in HASM cells. Our future studies will examine whether these mediators play a role in airway hyperresponsiveness and contribute to inflammation in the context of asthma through ELISA experimentations.

 

INCREASING THE EFFICIENCY OF THE TOPICAL MEDICATION TRIAMCINOLONE ACETONIDE IN THE ORAL CAVITY

The purpose of this project is to design a topical medication (ointment type) that is more efficient than the current commercialized triamcinolone acetonide medications (which are commonly applied on the oral cavity to cure cold sores and mouth ulcers) by adding double emulsion droplets (DEDs) and normal oral flora Streptococcus salivarius (SS) at various optimal conditions. The reason I decided to add SS and DEDs is that the SS can speed up the healing process and DEDs can act as a carrier for the SS and improve the viscosity of the ointment. I decided to introduce and test two different models: 1) model 1 in which the ointment acts a base and includes double emulsion droplets that encapsulate normal oral flora 2) model 2 which the double emulsion droplets encapsulate both the ointment and the normal oral flora. As a result, I was able to create my final design (model 2) using the saliva base when making W/O/W emulsion droplets and melting the ointment to mix in the oil base. I was also able to propose a simpler and more stable method (method 1) that simply includes double emulsion droplets and the normal oral flora in the current medication. However, to elongate the DED’s life span, there is still much more to be improved. Also, due to experimental constraints, I could only indirectly test how effectively the newly designed medication can heal a wound by measuring the adhesivity and absorbance. If I can test the medication on alive tissue through appropriate procedures, I would be able to get more reliable results.

 
 

MODELING A BIOLUMINESCENT POWER SOURCE THAT ENHANCES THE BRIGHTNESS OF PHOTOBACTERIUM PHOSPHOREUM WITH OPTIMIZED DYE-SENSITIZED PLATE

The problem with current similar products, such as bioluminescent lamps is that it is made by simply putting luminescent bacteria inside a container with food. Thus, it is not very applicable because the light is dark and colored; one can only use it as night or party light. My goal is to model a bio-luminescent LED (bLED) that is more applicable than the currently existing bio-luminescent products by combining Photobacterium Phosphoreum with a dye-sensitized solar cell(DSSC). I also aim to enhance the light of the bLED by optimizing culture conditions of the luminescent bacteria and the DSSC. The results were put together to make a finalized bLED. The brightness was 89.5[lx], and the power saved for 30 LEDs was 58.2[W]. The error was 0.11[W]. Conclusions/Discussion The bLED can emit continuous light because the DSSC can re-emit energy as brighter light when necessary. Theoretically, it also can be an indefinite cycle if the growth rate of bacteria is controlled properly. Thus, to maintain the growth rate I found optimal culturing conditions that is not previously determined. In the future I will attempt to minimize project constraints and do correlated research to increase the efficiency of DSSC.

 

DESIGNING A GRAPHENE BASE SOLAR CELL BY COMBINING SOLAR PHOTOVOLTAIC AND SOLAR HEAT POWER GENERATION

Existing solar cells collect sunlight to generate electricity, so the efficiency decreases when temperature rises or dust accumulates due to solar energy. I studied how to solve the ironic situation where the efficiency decreases when the temperature increases, for solar cells that operate only by collecting solar energy. However, yellow dust and fine dust is becoming a more of a problem. During spring time, pine pollen is added and the damage of dust is getting worse than ever. Solar cells have a lifespan of 20 years, so management is important, as they have to be cleaned regularly with distilled water. Although this method is great for batteries, it is a huge cost of human labor. Therefore, I studied how to save the cleaning cost from the process. Titanium dioxide (TiO2) is a white pigment that’s insoluble in water, hydrochloric acid, dilute sulfuric acid, alcohol, and other organic solvents, and insoluble in acids other than hot and concentrated sulfuric acid. As it is stable against heat, it’s used in soft drinks to stop the destruction of nutrients from light or ultraviolet rays, discoloration, or fading. Using these properties, I studied the advantages of titanium dioxide coating that can reduce the number of washing times. Finally, I determined if graphene can be used to increase the efficiency of solar cells.

 

 DESIGNING A NOVEL TOOTHBRUSH FOR EFFICIENT TOOTHBRUSHING TECHNIQUES IN LINGUAL ORTHODONTICS 

 The correct brushing method we usually know is to brush your teeth from your gums to your teeth. In areas where food is chewed, such as molars, areas where food comes in contact should also be cleaned. However, after wearing the braces to correct the teeth, food was more often left between the teeth or the braces even if you brushed your teeth in this way. There was a hassle of having to remove food separately by using it. So there were many times I didn't brush my teeth properly. Then, after seeing the contents of lingual correction in the news, I suddenly thought that brushing would be more difficult in the case of lingual correction, which is not the normal correction I am doing, because I cannot see the brushing condition around the brace with my eyes. In particular, since there is no separate toothbrush for lingual orthodontic use, and a general orthodontic toothbrush is used together, I wondered whether the lingual orthodontic brushing would be as good as normal orthodontic. If food is left unremoved, it can lead to bad breath and a higher risk of tooth decay. In particular, if you do not manage the food that is caught in the area where the braces and teeth contact, the teeth will die and the shape of the brace will remain. Therefore, through this exploration, we would like to confirm whether or not a commonly used orthodontic toothbrush is effective for lingual orthodontic teeth, and to find out the degree of plaque and foreign matter removal around braces from lingual orthodontic teeth compared to normal and orthodontic teeth. 

 

COMPARING THE INSULATION EFFECT OF NATURAL INSULATION TO DESIGN AN ECO-FRIENDLY APARTMENT COMPLEX

Investigate the ways in which pre-industrial revolution people get their living energy, and compare the efficiencies of these technologies by finding and experimenting with natural sources of cooling, heating, and power, which are applicable to modern society. Explore the eco-friendly apartment complex that applied the past energy production method by combining the explored contents with the large-scale apartment complex which is one of the representative residential facilities of the present time.